Hormone-free NKTs provide relief by targeting parts of the brain and skin that are thought to help regulate body temperature. These medications work
HOW HORMONE-FREE NKTS WORK
NKTs may target just receptors called NK-3, or both NK-1 and NK-3 receptors (known as ‘dual NK receptor antagonists’).
NK-1 and NK-3 receptors are found on cells in your brain called KNDy* (pronounced ‘candy’) neurons. NK-1 receptors are also found in blood vessels in your skin.
KNDy neurons are thought to regulate temperature and sleep, but during menopause, falling oestrogen levels mean they become overactive.
When this happens, it makes your body’s temperature control system more sensitive, leading to hot flashes, sweating and sleep disturbances. NKTs work by addressing this overactivity, helping restore balance to your body’s control system.
BENEFITS OF HORMONE-FREE NKTS
NKTs are suitable if you prefer not to, or are unable to, use hormones. They can effectively ease symptoms such as
COMMON SIDE EFFECTS AND OTHER CONSIDERATIONS
While NKTs can help with menopausal symptoms, it is important to be aware of the potential side effects and other considerations associated with them. Possible side effects include headaches, fatigue, diarrhoea, stomachache, and mild drowsiness.
NKTs do not address all menopause-associated risks, such as bone loss. In addition, if your healthcare provider knows or suspects you have a liver disease (hepatic disorder), they may want to do regular checks while you are taking some hormone-free treatments to make sure your liver is working properly.
The decision to use hormone-free treatments should be made in consultation with your healthcare provider, who can provide personalised guidance based on your individual health history and risk factors.
*KNDy is short for kisspeptin, neurokinin B, and dynorphin. These are the names of the proteins made by the KNDy neuron. A neuron is a type of nerve cell that uses proteins and chemicals to send messages around your body.